Publications

Heiser CN, Simmons AJ, Revetta F, McKinley ET, Ramirez-Solano MA, Wang J, Kaur H, Shao J, Ayers GD, Wang Y, Glass SE, Tasneem N, Chen Z, Qin Y, Kim W, Rolong A, Chen B, Vega P, Drewes JL, Markham NO, Saleh N, Nikolos F, Vandekar S, Jones A, Washington MK, Roland JT, Chan KS, Schurpf T, Sears CL, Liu Q, Shrubsole MJ, Coffey RJ, Lau KS. Molecular cartography uncovers evolutionary and microenvironmental dynamics in sporadic colorectal tumors. Cell. 2023 in press

Shelton CD, Mo J, Shealy NG, Sing E, Yoo W, Thomas J, Fitz GN, Torres TP, Foegeding NJ, Zieba JK, Calcutt MW, Codreanu SG, Sherrod SD, McLean JA, Yang F, Markham NO, Liu M, Byndloss MX. An early-life microbiota metabolite protects against obesity by regulating intestinal lipid metabolism. Cell Host Microbe. 2023. 31(10):1604-1619.e10. PMID: 37794592. PMCID: PMC10593428.

Lunnemann HM, Shealy NG, Reyzer ML, Shupe JA, Green EH, Siddiqi U, Lacy DB, Byndloss MX, Markham NO. Cecum axis (CecAx) preservation reveals physiological and pathological gradients in mouse gastrointestinal epithelium. Gut Microbes. 2023. 15(1). PMID: 36872510. PMCID: PMC10012889.

Drewes JL*, Chen J*, Markham NO*, Knipple RJ, Domingue JC, Tam AJ, Chan JL, Kim L, McMann M, Stevens C, Dejea CM, Tomkovich S, Michel J, White JR, Mohammad F, Campodónico VL, Heiser CN, Wu X, Wu S, Ding H, Simner P, Carroll K, Shrubsole MJ, Anders RA, Walk S, Jobin C, Wan F, Coffey RJ, Housseau F, Lau KS, Sears CL. Human colon cancer-derived Clostridioides difficile strains drive colonic tumorigenesis in mice. Cancer Discovery. 2022. 12(8):1873-1885. PMID: 35678528. PMCID: PMC9357196.

Schapiro D, Yapp C, Sokolov A, Reynolds SM, Chen YA, Sudar D, Xie Y, Muhlich J, Arias-Camison R, Arena S, Taylor AJ, Nikolov M, Tyler M, Lin JR, Burlingame EA; Human Tumor Atlas Network, Chang YH, Farhi SL, Thorsson V, Venkatamohan N, Drewes JL, Pe'er D, Gutman DA, Herrmann MD, Gehlenborg N, Bankhead P, Roland JT, Herndon JM, Snyder MP, Angelo M, Nolan G, Swedlow JR, Schultz N, Merrick DT, Mazzili SA, Cerami E, Rodig SJ, Santagata S, Sorger PK. MITI minimum information guidelines for highly multiplexed tissue images. Nat Methods. 2022 Mar;19(3):262-267. PMID: 35277708; PMCID: PMC9009186.

Chen B, Scurrah CR, McKinley ET, Simmons AJ, Ramirez-Solano MA, Zhu X, Markham NO, Heiser CN, Vega PN, Rolong A, Kim H, Sheng Q, Drewes JL, Zhou Y, Southard-Smith AN, Xu Y, Ro J, Jones, AL, Revetta F, Berry L, Islam M, Pelka K, Hofree M, Chen J, Sarkizova S, Ng K, Giannakis M, Boland GM, Aguirre AJ, Anderson AC, Rozenblatt-Rosen O, Regev A, Hacohen N, Kawasaki K, Sato R, Goettel JA, Grady WM, Zheng W, Washington MK, Cai Q, Sears CL, Goldenring JR, Franklin JL, Su T, Huh WJ, Vandekar S, Roland JT, Liu Q, Coffey RJ, Shrubsole MJ, Lau KS. Human colorectal pre-cancer atlas identifies distinct molecular programs underlying two major subclasses of pre-malignant tumors. Cell. 2021. 184(26):6262-6280. PMID: 34910928. PMCID: PMC8941949.

Monaghan TM, Seekatz AM, Markham NO, Yau TO, Hatziapostolou M, Jilani T, Christodoulou N, Roach B, Birli E, Pomenya O, Louie T, Lacy DB, Kim P, Lee C, Kao D, Polytarchou C. Fecal microbiota transplantation for recurrent Clostridioides difficile infection associates with functional alterations in circulating microRNAs. Gastroenterology. 2021. Jul;161(1):255-270.e4. PMID: 33844988. PMC8579492.

Marincola Smith P, Choksi Y, Markham NO, Hanna D, Zi J, Weaver C, Hamaamen J, Lewis K, Yang J, Liu Q, Kaji I, Means A, Beauchamp RD. Colon epithelial cell TGFβ signaling modulates the expression of tight junction proteins and barrier function in mice. American Journal of Physiology-Gastrointestinal and Liver Physiology. 2021. Jun 1;320(6):G936-G957. PMID: 33759564. PMC8285585.

Markham NO*, Bloch SC*, Shupe JA*, Laubacher EN, Thomas AK, Kroh HK, Childress KO, Peritore-Galve FC, Washington MK, Coffey RJ, Lacy DB. Murine Intrarectal Instillation of Purified Recombinant Clostridioides difficile Toxins Enables Mechanistic Studies of Pathogenesis. Infection and Immunity. 2021. Mar 17;89(4):e00543-20. PMID: 33468584. PMC8090962.

Macedonia MC, Drewes JL, Markham NO, Simmons AJ, Roland JT, Vega PN, Scurrah CR, Coffey RJ, Shrubsole MJ, Sears CL, Lau KS. Clinically adaptable polymer enables simultaneous spatial analysis of colonic tissues and biofilms. NPJ Biofilms and Microbiomes. 6(1):33. 2020.

Rozenblatt-Rosen O, Regev A, Oberdoerffer P, Nawy T, Hupalowska A, Rood JE, Ashenberg O, Cerami E, Coffey RJ, Demir E, Ding L, Esplin ED, Ford JM, Goecks J, Ghosh S, Gray JW, Guinney J, Hanlon SE, Hughes SK, Hwang ES, Iacobuzio-Donahue CA, Jané-Valbuena J, Johnson BE, Lau KS, Lively T, Mazzilli SA, Pe’er D, Santagata D, Shalek AK, Schapiro D, Snyder MP, Sorger PK, Spira AE, Srivastava S, Tan K, West RB, Williams EH, and the Human Tumor Interaction Network. The Human Tumor Atlas Network: Charting Tumor Transitions across Space and Time at Single-Cell Resolution. Cell. 181(2):236-249. 2020.

Cao Z, Singh B, Li C, Markham NO, Carrington LJ, Franklin JL, Graves-Deal R, Kennedy EJ, Goldenring JR, and Coffey RJ. PKA-mediated phosphorylation of NKD2 stimulates cell-surface delivery of TGF-α for EGFR transactivation. Traffic. 20(5):357-368. 2019.

Markham NO, Huh WJ, and Coffey RJ. Linking ALDH1 and retinoic acid signaling. Oncotarget. 10(12):1226-1227. 2019.

Markham NO, Naik RD, Roberts JA, Yachimski PS. A case of hepatic Kaposi's sarcoma diagnosed by transgastric biopsy. Gastrointestinal Endoscopy. 88(1):188-189. 2018.

Yu HH, Dohn MR, Markham NO, Coffey RJ, Reynolds AB. p120-catenin controls contractility along the vertical axis of epithelial lateral membranes. Journal of Cell Science. 129(1):80-94. 2015.

Markham NO, Doll CA, Dohn MR, Yu H, Miller RK, McCrea PD, Gamse JT, Reynolds AB. DIPA family coiled-coils bind conserved head domain of p120-catenin family: potential roles in N-cadherin associated disease. Molecular Biology of the Cell. 25(17):2592-603. 2013.

Markham NO, Cooper T, Goff M, Gribben EM, Carnahan R, Reynolds AB. Monoclonal Antibodies to DIPA: a novel binding partner of p120-catenin isoform 1. Hybridoma. 31(4):246-54. 2012.

Barrett CW, Smith JJ, Lu LC, Markham NO, Stengel KR, Short SP, Zhang B, Hunt AA, Fingleton BM, Carnahan RH, Engel ME, Chen X, Beauchamp RD, Wilson KT, Hiebert SW, Reynolds AB, Williams CS. Kaiso directs the transcriptional corepressor MTG16 to the Kaiso binding site in target promoters. PLoS ONE. 7(12):e51205. 2012.

Meredith M, Parry EM, Guay J, Markham NO, Danner RG, Johnson K, Barkay T, Fekete FA. Concomitant antibiotic and mercury resistance among gastrointestinal microflora of feral brook trout, Salvelinus fontinalis. Current Microbiology. 65(5):575-82. 2012.

Stefanovic M, Markham NO*, Parry EM, Garrett-Beal LJ, Cline AP, Gallagher PG, Low PS, Bodine DM. An 11-amino acid β-hairpin loop in the cytoplasmic domain of band 3 is responsible for ankyrin binding in mouse erythrocytes. Proc Natl Acad Sci U S A. 104(35):13972-7. 2007.

*Equal contribution